@article{10272/19636,
year = {2019},
month = {6},
url = {http://hdl.handle.net/10272/19636},
abstract = {The dual function of the N-F bond as an effective oxidant and subsequent nitrogen source in intramolecular aliphatic C-H functionalization reactions is explored. Copper catalysis is demonstrated to exercise full regio- and chemoselectivity control, which opens new synthetic avenues to nitrogenated heterocycles with predictable ring sizes. For the first time, a uniform catalysis manifold has been identified for the construction of both pyrrolidine and piperidine cores. The individual steps of this new copper oxidation catalysis were elucidated by control experiments and computational studies, clarifying the singularity of the N-F function and characterizing the catalytic cycle to be based on a copper(I/II) manifold.},
organization = {We thank MINECO for Grants CTQ2017-82893-C2-1-R, 
CTQ2017-87792-R, CTQ2017-88496-R, COST Action CA15106 
“C–H Activation in Organic Synthesis (CHAOS)”and Red Intecat 
(CTQ2016-81923-REDC).},
publisher = {Wiley},
title = {Copper-Catalyzed N-F Bond Activation for Uniform Intramolecular C-H Amination Yielding Pyrrolidines and Piperidines},
doi = {10.1002/anie.201902716},
author = {Bafaluy, Daniel and Muñoz Molina, José María and Funes Ardoiz, Ignacio and Herold, Sebastian and Aguirre, Adiran J. de and Zhang, Hongwei and Maseras, Feliu and Rodríguez Belderraín, Tomás and Pérez Romero, Pedro José and Muñiz, Kilian},
}