RT Journal Article
T1 Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones
A1 González Domínguez, Álvaro
A1 Domínguez Riscart, Jesús
A1 Millán Martínez, María
A1 Lechuga Sancho, Alfonso María
A1 González Domínguez, Raúl
AB Although growing evidence points to a pivotal role of perturbed metal homeostasisin childhood obesity, sexual dimorphisms in this association have rarelybeen investigated. In this study, we applied multi-elemental analysis to plasmaand erythrocyte samples from an observational cohort comprising childrenwith obesity, with and without insulin resistance, and healthy control children.Furthermore, a wide number of variables related to carbohydrate and lipidmetabolism, inflammation, and sex hormones were also determined. Childrenwith obesity, regardless of sex and insulin resistance status, showed increasedplasma copper-to-zinc ratios. More interestingly, obesity-related erythroidalterations were found to be sex-dependent, with increased contents of iron,zinc, and copper being exclusively detected among female subjects. Our findingssuggest that a sexually dimorphic hormonal dysregulation in response toa pathological cascade involving inflammatory processes and hyperinsulinemiacould be the main trigger of this female-specific intracellular sequestration oftrace elements. Therefore, the present study highlights the relevance of genotypicsex as a susceptibility factor influencing the pathogenic events behindchildhood obesity, thereby opening the door to develop sex-personalizedapproaches in the context of precision medicine.
PB Wiley
SN 0951-6433
SN 1872-8081 (electrónico)
YR 2023
FD 2023
LK https://hdl.handle.net/10272/22149
UL https://hdl.handle.net/10272/22149
LA eng
NO González‐Domínguez, Á., Domínguez‐Riscart, J., Millán‐Martínez, M., Lechuga‐Sancho, A. M., & González‐Domínguez, R. (2023). Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones. In BioFactors. Wiley. https://doi.org/10.1002/biof.1948
NO INiBICA, Grant/Award Number: LII19/16IN-CO24; Instituto de Salud Carlos III, Grant/Award Numbers: CP21/00120, PI22/01899
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026