RT Journal Article
T1 Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure
A1 López Baltanás, Rodrigo
A1 Canalejo Raya, Antonio
A1 Muñoz Castañeda, Juan R.
AB Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonlyassociated with cardiovascular disease (CVD) and in these patients Mg concentration is usuallydecreased. This study evaluated whether a dietary Mg supplementation might attenuate vasculardysfunction through the modulation of oxidative stress and inflammation in concurrent MetS andCKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 nephrectomy, Nx) was used.Nephrectomized animals were fed a normal 0.1%Mg (MetS+Nx+Mg 0.1%) or a supplemented 0.6%Mg(MetS+Nx+Mg0.6%) diet; Sham-operated rats with MetS receiving 0.1%Mg were used as controls.Results: As compared to controls, the MetS+Nx-Mg0.1% group showed a significant increase inoxidative stress and inflammation biomarkers (lipid peroxidation and aortic interleukin-1b and-6 expression) and Endothelin-1 levels, a decrease in nitric oxide and a worsening in uremia and MetSassociated pathology as hypertension, and abnormal glucose and lipid profile. Moreover, proteomicevaluation revealed changes mainly related to lipid metabolism and CVD markers. By contrast, inthe MetS+Nx+Mg0.6% group, these parameters remained largely similar to controls. Conclusion: Inconcurrent MetS and CKD, dietary Mg supplementation reduced inflammation and oxidative stressand improved vascular function.
PB MDPI
SN 2076-3921 (electrónico)
YR 2023
FD 2023-01
LK https://hdl.handle.net/10272/22232
UL https://hdl.handle.net/10272/22232
LA eng
NO López-Baltanás, R., Rodríguez-Ortiz, M. E., Díaz-Tocados, J. M., Martinez-Moreno, J. M., Membrives, C., Rodelo-Haad, C., Pendón Ruiz de Mier, M. V., Rodríguez, M., Canalejo, A., Almadén, Y., & Muñoz-Castañeda, J. R. (2023). Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure. In Antioxidants (Vol. 12, Issue 2, p. 283). MDPI AG. https://doi.org/10.3390/antiox12020283
NO This research was funded by a Spanish government grant from the Programa NacionalI+D+I 2008–2011 from the MINECO-Instituto de Salud Carlos III (PI20/0660 and PI21/00654) withco-financing from European Funds (FEDER) and EUTOX and REDinREN from the ISCIII, Consejeríade Salud (grants PI-0071-2021) from the Junta de Andalucía and Grant PY20_00773 from Consejeríade Innovación, Ciencia y Empleo from the Junta de Andalucía. J.M.D.-T. hold a Sara Borrell contractby the Spanish Ministry of Science, Innovation and Universities, Carlos III Health Institute (ISCIII),co-funded by European Social Fund (European Social Fund-Investment in your future). Y.A. andJ.R.M.-C. are senior researchers supported by the Nicolás Monardes Programme, Consejería deSalud-SAS (Junta de Andalucía).
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026