@article{10272/18922,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10272/18922},
abstract = {We aimed to study the association between occupational exposure to pesticides and
chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides,
four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish
population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain,
2010–2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs
the product of prevalence, intensity and duration of exposure to each active substance. Principal
components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and
occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed
to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of
CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend;
2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA,
the first component (PC1, explaining 70% of the variation) equally led by seven active substances
(the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of
having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm
previous associations between CLL and exposure to pesticides and provide additional evidence
by application groups and active substance. However, more research is needed to disentangle
independent effects of individual active substances.},
organization = {The authors would like to thank all the subjects for their contribution to the study and the MCC-Spain-CLL collaborators from: Catalan Institute of Oncologia, L’Hospitalet de Llobregat, Barcelona,
Spain (Teresa Alonso, Vanesa Camon, Eva Domingo-Domenech, Dolores Dot, Anna Esteban, Elisabeth Guinó, Yolanda Florencia, Joellen Klaustermeier, Santi Mercadal, Ana Oliveira, Isabel Padrol, Paloma Quesada, Victor Moreno, Josep Sarra, Yasmin Sabat
é, Marleny Vergara); Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain (Mireia García, Cecília Persavento); Hospital Clínic, Barcelona, Spain (Cristina Capdevila Lozar, Ainara Expósito, Silvia Martin Román, Amparo Muñoz, Yolanda Torralba); Hospital del Mar, Barcelona, Spain (Eugènia
Abella, Estela Carrasco, Judith Cirac, Francesc Garcia, Antonio Salar); Hospital Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain (Esmeralda de la Banda); Institut de Prestacions d’Assistè
ncia Mèdica al Personal Municipal (PAMEM) & Centros de Atención Primaria (CAP), Barcelona, Spain (Jesús Almeda, Marifé Alvarez Rodriguez,
Alex Bassa Massanas, Albert Boada Valmaseda, Enric Duran, Olga Gonzalez Ferrer, Clara Izard, Manoli Liceran, Carmen López, Josep Manuel Bení
tez, Dolors Petitbó, Angelina Potrony, S
ònia Sarret, Laura Sebastián, Josep M.
Vilaseca); Cantabria group (Inés Gómez-Acebo, Pilar González Echezarreta, Maria del Mar González Mart
ínez, Javier Llorca, Luis Mariano López López, Almudena de la Pedraja Pavón, Paula Picón Sedano); Instituto Universitario de Oncologí
a, Universidad de Oviedo, Asturias, Spain (Cristina Arias, Guillermo Fernández, María José Fernández González, Ana Fernández Somoano, Carlos López-Ot
ín, Ana Souto); Servicio de Salud del Principado de Asturias, SESPA, Asturias, Spain (Enrique Colado, Begoña Martínez-Argüelles, Manuel Rivas
del Fresno, Marta María Rodríguez-Suá
rez); Departemento de Medicina Preventiva y Salud P
ública, Instituto de Investigación Biosanitaria de Granada, Hospitales Universitarios de Granada
/Universidad de Granada (Jose Juan Jiménez-Mole
ón, Aurora Bueno Cavanillas, Obdulia Moreno Abril); Ciber de Epidemiología y Salud Pública(CIBEResp) (Rocío Olmedo Requena); Servicio de Hematologí
a, Hospital Universitario Virgen de las Nieves, Jos
é Luis Gastón Morata Centro de Salud Zaidí
n Sur, Servicio Andaluz de Salud (Paloma Garcí
a-Martín, Eva Garrido Morales); Unitat d’Epidemiologia i Registre de Cancer de Girona (Maria Buxo, M Carme Carmona-Garcia, Angel Izquierdo, Rafael Marcos-Gragera, Patricia Martí
Bargalló, Gemma Osca-Gelis, Montse Puig-Vives, RocioRodriguez Romanos, Esther Rodriguez Sanchez, Marc Saez, Carlota Torner Galindo, Loreto Vilardell); HospitalUniversitari de Girona. Josep Trueta (Elena Alvarez Castaño, Ignacio Blanco, Rosa Coll, David Gallardo, JosepMaria Roncero, Luis Miguel Alonso Ruano); Hospital Santa Caterina (Rocio Jurado Perez, Isaura Marcé Pujol, Joan
Melendez Rusiñol); CAP de Santa Clara (Conxa Bou); CAP de Angles (Gabriel Coll de Tuero, Alba Coll Negre).},
publisher = {MDPI},
title = {Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study},
doi = {10.3390/ijerph17145174},
author = {Benavente, Yolanda and Costas, Laura and Rodríguez Suárez, Marta María and Alguacil Ojeda, Juan},
}