RT Journal Article
T1 Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
A1 Benavente, Yolanda
A1 Costas, Laura
A1 Rodríguez Suárez, Marta María
A1 Alguacil Ojeda, Juan
AB We aimed to study the association between occupational exposure to pesticides andchronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides,four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanishpopulation (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain,2010–2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobsthe product of prevalence, intensity and duration of exposure to each active substance. Principalcomponents analysis (PCA) and logistic regression models adjusted for age, sex, region, education andoccupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposedto one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) ofCES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend;2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA,the first component (PC1, explaining 70% of the variation) equally led by seven active substances(the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds ofhaving CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirmprevious associations between CLL and exposure to pesticides and provide additional evidenceby application groups and active substance. However, more research is needed to disentangleindependent effects of individual active substances.
PB MDPI
SN 1660-4601
YR 2020
FD 2020-07
LK http://hdl.handle.net/10272/18922
UL http://hdl.handle.net/10272/18922
LA eng
NO Benavente, Y., Costas, L., Rodríguez Suárez, M. M. ... Alguacil Ojeda, J. (2020). Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study. International Journal of Environmental Research and Public Health, 17(14), 5174. DOI:  https://doi.org/10.3390/ijerph17145174
NO The authors would like to thank all the subjects for their contribution to the study and the MCC-Spain-CLL collaborators from: Catalan Institute of Oncologia, L’Hospitalet de Llobregat, Barcelona,Spain (Teresa Alonso, Vanesa Camon, Eva Domingo-Domenech, Dolores Dot, Anna Esteban, Elisabeth Guinó, Yolanda Florencia, Joellen Klaustermeier, Santi Mercadal, Ana Oliveira, Isabel Padrol, Paloma Quesada, Victor Moreno, Josep Sarra, Yasmin Sabaté, Marleny Vergara); Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain (Mireia García, Cecília Persavento); Hospital Clínic, Barcelona, Spain (Cristina Capdevila Lozar, Ainara Expósito, Silvia Martin Román, Amparo Muñoz, Yolanda Torralba); Hospital del Mar, Barcelona, Spain (EugèniaAbella, Estela Carrasco, Judith Cirac, Francesc Garcia, Antonio Salar); Hospital Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain (Esmeralda de la Banda); Institut de Prestacions d’Assistència Mèdica al Personal Municipal (PAMEM) & Centros de Atención Primaria (CAP), Barcelona, Spain (Jesús Almeda, Marifé Alvarez Rodriguez,Alex Bassa Massanas, Albert Boada Valmaseda, Enric Duran, Olga Gonzalez Ferrer, Clara Izard, Manoli Liceran, Carmen López, Josep Manuel Benítez, Dolors Petitbó, Angelina Potrony, Sònia Sarret, Laura Sebastián, Josep M.Vilaseca); Cantabria group (Inés Gómez-Acebo, Pilar González Echezarreta, Maria del Mar González Martínez, Javier Llorca, Luis Mariano López López, Almudena de la Pedraja Pavón, Paula Picón Sedano); Instituto Universitario de Oncología, Universidad de Oviedo, Asturias, Spain (Cristina Arias, Guillermo Fernández, María José Fernández González, Ana Fernández Somoano, Carlos López-Otín, Ana Souto); Servicio de Salud del Principado de Asturias, SESPA, Asturias, Spain (Enrique Colado, Begoña Martínez-Argüelles, Manuel Rivasdel Fresno, Marta María Rodríguez-Suárez); Departemento de Medicina Preventiva y Salud Pública, Instituto de Investigación Biosanitaria de Granada, Hospitales Universitarios de Granada/Universidad de Granada (Jose Juan Jiménez-Moleón, Aurora Bueno Cavanillas, Obdulia Moreno Abril); Ciber de Epidemiología y Salud Pública(CIBEResp) (Rocío Olmedo Requena); Servicio de Hematología, Hospital Universitario Virgen de las Nieves, José Luis Gastón Morata Centro de Salud Zaidín Sur, Servicio Andaluz de Salud (Paloma García-Martín, Eva Garrido Morales); Unitat d’Epidemiologia i Registre de Cancer de Girona (Maria Buxo, M Carme Carmona-Garcia, Angel Izquierdo, Rafael Marcos-Gragera, Patricia MartíBargalló, Gemma Osca-Gelis, Montse Puig-Vives, RocioRodriguez Romanos, Esther Rodriguez Sanchez, Marc Saez, Carlota Torner Galindo, Loreto Vilardell); HospitalUniversitari de Girona. Josep Trueta (Elena Alvarez Castaño, Ignacio Blanco, Rosa Coll, David Gallardo, JosepMaria Roncero, Luis Miguel Alonso Ruano); Hospital Santa Caterina (Rocio Jurado Perez, Isaura Marcé Pujol, JoanMelendez Rusiñol); CAP de Santa Clara (Conxa Bou); CAP de Angles (Gabriel Coll de Tuero, Alba Coll Negre).
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026