RT Journal Article T1 The MOBI-Kids study protocol: challenges in assessing childhood and adolescent exposure to electromagnetic fields from wireless telecommunication technologies and possible association with brain tumor risk A1 Sadetzki, Siegal A1 Langer, Chelsea Eastman A1 Bruchim, Revital A1 Alguacil Ojeda, Juan AB The rapid increase in mobile phone use in young people has generated concern about possiblehealth effects of exposure to radiofrequency (RF) and extremely low frequency (ELF)electromagnetic fields (EMF). MOBI-Kids, a multinational case–control study, investigatesthe potential effects of childhood and adolescent exposure to EMF from mobile communicationstechnologies on brain tumor risk in 14 countries. The study, which aims to includeapproximately 1,000 brain tumor cases aged 10–24 years and two individually matchedcontrols for each case, follows a common protocol and builds upon the methodologicalexperience of the INTERPHONE study. The design and conduct of a study on EMF exposureand brain tumor risk in young people in a large number of countries is complex andposes methodological challenges.This manuscript discusses the design of MOBI-Kids anddescribes the challenges and approaches chosen to address them, including: (1) the choiceof controls operated for suspected appendicitis, to reduce potential selection bias relatedto lowresponse rates among population controls; (2) investigating a young study populationspanning a relatively wide age range; (3) conducting a large, multinational epidemiologicalstudy, while adhering to increasingly stricter ethics requirements; (4) investigating arare and potentially fatal disease; and (5) assessing exposure to EMF from communicationtechnologies. Our experience in thus far developing and implementing the study protocolindicates that MOBI-Kids is feasible and will generate results that will contribute to theunderstanding of potential brain tumor risks associated with use of mobile phones andother wireless communications technologies among young people. PB Frontiers Media SN 2296-2565 YR 2014 FD 2014-09 LK http://hdl.handle.net/10272/18364 UL http://hdl.handle.net/10272/18364 LA eng NO Sadetzki, S., Langer, C. E., Bruchim, R. ... Alguacil Ojeda, J. (2014). The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Technologies and Possible Association with Brain Tumor Risk. Frontiers in Public Health, vol. 2, art. 124. DOI: https://doi.org/10.3389/fpubh.2014.00124 NO We would like to thank all of the research assistants and interviewers in the study centers for their enormous efforts to ensure the research leading to these results has received funding from by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number 22687 3 the MOBI-Kids project. International coordination of the project is partly supported by a grant from the Spanish Ministry of Science and Innovation (MICCIN). Australia: Australian participation in MOBI-Kids is supported by the Australian National Health and Medical Research Council with a five-year research grant (grant number: 546130 and Chief Investigators are: Malcolm R. Sim, Bruce Armstrong, Elizabeth Milne, and Geza Benke). Austria: Austrian participation in MOBI-Kids is partly supported by a grant from the Ministry of Science. Canada: Canadian participation in MOBI-Kids is supported by a university industry partnership grant from the Canadian Institutes of Health Research (CIHR), with the Canadian Wireless Telecommunications Association (CWTA) serving as the industrial partner. CWTA provides technical information on wireless telecommunications in Canada and facilitates access to billing records from Canadian network operators, but has no involvement in the design, conduct, analysis, or interpretation of the MOBI-KIDS study. Health Canada has also provided financial support to facilitate coordination between Canadian and international MOBI-Kids investigators. Daniel Krewski is the Natural Sciences and Engineering Research Council of Canada Chair in Risk Science at the University of Ottawa. France: this project received funds from the French National Agency for Sanitary Safety of Food, Environment and Labour (ANSES, contract FSRF 2008-3), French National Cancer Institute (INCa), Pfizer Foundation and League against cancer. Germany: the German branch of MOBI-Kids is supported by the Federal Office for Radiation Protection. Greece: Greek participation is partially supported by ELKE (Special Account for Research Grants of the National and Kapodistrian University of Athens) and GGET (General Secretariat for Research and Technology). India: MOBI-Kids India is supported by the Board of Research in Nuclear Sciences (BRNS). Italy: Ministry of Health RF-2009-1546284. Japan: Japanese participation in MOBI-Kids is supported by the Ministry of Internal Affairs and Communications. Korea: MOBI-Kids Korea is financially supported by the Ministry of Science, ICT and Future Planning (MSIP), Korea in the ICT R&D Program. New Zealand: MOBI-Kids New Zealand is supported by grants from Cure Kids New Zealand and the New Zealand Health Research Council. Spain: Spanish participation is partially supported by the Spanish Health Research Fund (FIS PI10/02981), the Andalusian Consejeria de Salud (PI-0317/2010) and Conselleria de Sanitat, Generalitat Valenciana under grant number 025/2010. The Netherlands: Dutch participation in MOBI-KIDS is partly supported by The Netherlands Organisation for Health Research and Development (ZonMw) within the program Electromagnetic Fields and Health Research under grant number 85800001, and by the ODAS foundation, a private foundation supporting activities in the field of pediatric oncology and visual disabilities. DS Repositorio Institucional de la Universidad de Huelva RD 31 may 2026