RT Journal Article
T1 Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients
A1 Bernabeu Wittel, Máximo
A1 González Molina, Álvaro
A1 Fernández Ojeda, Rocío
A1 Gómez Salgado, Juan
AB The prevalence, relationships and outcomes of sarcopenia and frailty in polypathologicalpatients remain unknown. We performed a multicenter prospective observational study in sixhospitals in order to assess prevalence, clinical features, outcome and associated risk factors ofsarcopenia and frailty in a hospital-based population of polypathological patients. The cohort wasrecruited by performing prevalence surveys every 14 days during the inclusion period (March2012–June 2016). Sarcopenia was assessed by means of EWGSOP criteria and frailty by means ofFried’s criteria. Skeletal muscle mass was measured by tetrapolar bioimpedanciometry. All patientswere followed for 12 months. Factors associated with sarcopenia, frailty and mortality were analyzedby multivariate logistic regression, and Kaplan–Meier curves. A total of 444 patients (77.3   8.4years, 55% males) were included. Sarcopenia was present in 97 patients (21.8%), this being moderatein 54 (12.2%), and severe in 43 (9.6%); frailty was present in 278 patients (62.6%), and 140 (31.6%)were pre-frail; combined sarcopenia and frailty were present in the same patient in 80 (18%) patients.Factors independently associated to the presence of both, sarcopenia and frailty were female gender,older age, di erent chronic conditions, poor functional status, low body mass index, asthenia anddepressive disorders, and low leucocytes and lymphocytes count. Mortality in the 12-monthsfollow-up period was 40%. Patients with sarcopenia, frailty or both survived significantly less thanthose without these conditions. Sarcopenia and frailty are frequent and interrelated conditions inpolypathological patients, shadowing their survival. Their early recognition and management couldimprove health-related outcomes in this population.
PB MDPI
SN 2077-0383
YR 2019
FD 2019-04
LK http://hdl.handle.net/10272/16490
UL http://hdl.handle.net/10272/16490
LA eng
NO Bernabeu Wittel, M., González Molina, Á., Fernández Ojeda, R. … Gómez Salgado, J. (2019). Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients. Journal of Clinical Medicine, 8(4), 535. DOI: https://doi.org/10.3390/jcm8040535
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026