RT Journal Article
T1 Impact of “chemical cocktails” exposure in shaping mice gut microbiota and the role of selenium supplementation combining metallomics, metabolomics, and metataxonomics
A1 Arias Borrego, Ana
A1 Selma Royo, Marta
A1 Collado, Maria Carmen
A1 Abril, Nieves
A1 García Barrera, Tamara
AB Biological systems are exposed to a complex environment in which pollutants can interact through synergistic or antagonistic mechanisms, but limited information is available on the combined effects. To this end, conventional and antibiotic-treated (Abx) mice models were fed regular rodent or selenium (Se) supplemented diets and exposed to a “chemical cocktail” (CC) including metals and pharmaceuticals. Metallomics, metabolomics, and metataxomics were combined to delve into the impact on gut microbiota, plasma selenoproteome, metabolome,and arsenic metabolization. At the molecular level, Se decreased the concentration of the antioxidant glutathione peroxidase in plasma and increased the arsenic methylation rate, possibly favoring its excretion, but not in the Abx and also plasma metabolomes of Abx, and Abx-Se were not differentiated. Moreover, numerous associations were obtained between plasma selenoproteins and gut microbes. Se-supplementation partially antagonizes the gut microbiota alteration caused by Abx, and slightly by CC, but strongly altered profiles were observed in CCAbx-Se, suggesting synergistic deleterious effects between pollutants, Abx and Se. Moreover, although CC and Abx changed gut microbiota, several common taxa were enriched in CC-Abx and control mice, indicating possible synergistic effects. Our results suggest a potential beneficial impact of supplementation, but mediated by gut microbes being reversed in their absence. 
PB Elsevier
YR 2022
FD 2022-06-20
LK http://hdl.handle.net/10272/21250
UL http://hdl.handle.net/10272/21250
LA eng
NO Arias-Borrego, A., Selma-Royo, M., Collado, M. C., Abril, N., & García-Barrera, T. (2022). Impact of “chemical cocktails” exposure in shaping mice gut microbiota and the role of selenium supplementation combining metallomics, metabolomics, and metataxonomics. Journal of Hazardous Materials, 438, 129444. https://doi.org/10.1016/j.jhazmat.2022.129444
NO This work was supported by the projects: PG2018–096608-B-C21 from the Spanish Ministry of Science and Innovation (MICIN). Generaci´on del Conocimiento. MCIN/ AEI /10.13039/501100011033/ FEDER “Una manera de hacer Europa’’, UHU-1256905 and UHU- 202009 from the FEDER Andalusian Operative Program 2014–2020 (Ministry of Economy, Knowledge, Business and Universities, Regional Government of Andalusia, Spain). The authors are grateful to FEDER (European Community) for financial support, Grant UNHU13–1E-1611. Funding for open access charge: Universidad de Huelva / CBUA. The authors would like to acknowledge the support from The Ram´on Areces Foundation (ref. CIVP19A5918).
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026