RT Journal Article
T1 Predictors of subclinical atherosclerosis in HIV
A1 Fernández Soto, Julia
A1 Romero Jiménez, Manuel Jesús
A1 Alarcón García, José Carlos
A1 Bonet Estruch, Elena
A1 Sánchez Ramos, José Luis
A1 Castaño López, Miguel Ángel
AB Background Cardiovascular disease is a major cause of morbidity and mortality in people with HIV. The detection of subclinical atherosclerosis through vascular ultrasound allows us to identify patients at an increased risk of cardiovascular disease as a primary prevention strategy; this test is not routine. Our objective is to identify predictors of subclinical atherosclerosis in a population with HIV. Methods People with HIV infection were selected for primary prevention and underwent carotid and femoral ultrasound to detect atheromatous plaques. Logistic regression analysis including vascular risk factors was performed to predict the presence of atherosclerosis. Results One hundred eighty-three patients were included, 54% of whom were smokers; the mean duration of HIVinfection was 9.52 years, and all patients were undergoing antiretroviral treatment. Subclinical atherosclerosis was present in 62.29% of the patients; 83.32% had plaque in the carotid territory, 57.93% in the femoral territory and 25.6% in both vascular territories. Compared to those without atherosclerosis, patients with atherosclerosis were on average 5.35 years older (53.86 vs. 48.51, p < 0.001) and had a higher prevalence of smoking (63.23% vs. 39.12%, p = 0.020) anda CD4/CD8 ratio below 0.7 (44.23% vs. 29.02%, p = 0.043). A CD4/CD8 ratio lower than 0.3 was always associated with subclinical atherosclerosis (95% confidence interval (CI): 83.9–100%). The inclusion of smoking, the CD4/CD8 ratio and age in the logistic regression analysis led to a diagnostic yield of 72% measured by the area under the receiving operator characteristic (ROC) curve (95% CI: 64–80%). Conclusions Tobacco use, age and a CD4/CD8 ratio below 0.7 allow prediction of the presence of subclinical atherosclerosis in primary prevention. A CD4/CD8 ratio below 0.3 was a diagnostic indicator of atherosclerosis in HIV patients undergoing primary prevention in our sample.
PB Springer Science and Business Media LLC.
SN 1471-2334 (electrónico)
YR 2023
FD 2023
LK https://hdl.handle.net/10272/22283
UL https://hdl.handle.net/10272/22283
LA eng
NO Fernández Soto, J., Romero-Jiménez, M. J., Alarcón García, J. C., Bonet Estruch, E., Sánchez Ramos, J. L., & Castaño López, M. Á. (2023). Predictors of subclinical atherosclerosis in HIV. In BMC Infectious Diseases (Vol. 23, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12879-022-07976-1
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026