RT Journal Article
T1 Shift work and colorectal cancer risk in the MCC-Spain case–control study
A1 Papantoniou, Kyriaki
A1 Lorca Marín, José Andrés
A1 Kogevinas, Manolis
AB Objectives Shift work that involves circadian disruption has been associated with a higher cancer risk. Most epidemiological studies to date have focused on breast cancer risk and evidence for other common tumors is limited. We evaluated the risk for colorectal cancer (CRC) in relation to shift work history in a population-based case-control study in Spain. Methods This analysis included 1626 incident CRC cases and 3378 randomly selected population controls of both sexes, enrolled in 11 regions of Spain. Sociodemographic and lifestyle information was assessed in face-to-face interviews. Shift work was assessed in detail throughout lifetime occupational history. We estimated the risk of colon and rectal cancer associated with rotating and permanent shift work (ever, cumulative duration, age of first exposure) using unconditional logistic regression analysis adjusting for potential confounders. Results Having ever performed rotating shift work (morning, evening and/or night) was associated with an increased risk for CRC [odds ratio (OR) 1.22, 95% confidence interval (95% CI) 1.04-1.43], as compared to day workers. Having ever worked permanent night shifts (≥3 nights/month) was not associated with CRC risk (OR 0.79, 95% CI 0.62-1.00). OR increased with increasing lifetime cumulative duration of rotating shift work (P-value for trend 0.005) and were highest among subjects in the top quartiles of exposure (3 rdquartile, 20-34 years, OR 1.38, 95%CI 1.06-1.81; 4 thquartile, ≥35 years, OR 1.36, 95% CI 1.02-1.79). Conclusions These data suggest that rotating shift work may increase the risk of CRC especially after long-term exposures.
PB Nordic Association of Occupational Safety and Health
SN 0355-3140
SN 1795-990X (electrónico)
YR 2017
FD 2017
LK http://hdl.handle.net/10272/16192
UL http://hdl.handle.net/10272/16192
LA eng
NO Papantoniou, K., Castaño-Vinyals, G., Espinosa, A., Turner, M. C., Alonso-Aguado, M. H., Martin, V., Lorca Marín, J.A., Kogevinas, M... et al. (2017). Shift work and colorectal cancer risk in the MCC-Spain case–control study. Scandinavian Journal of Work, Environment & Health, 43(3), 250-259. https://doi.org/10.5271/sjweh.3626
NO The study was funded by the "Accion Transversal del Cancer", approved on the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-Leon, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundacion Marques de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economia y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Tematica de Investigacion del Cancer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y Leon (LE22A10-2), by the Consejeria de Salud of the Junta de Andalucia (2009-S0143), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government DURSI grant 2009SGR1489, and by a predoctoral grant PFIS (FI09/00385). VM was co-funded by FEDER funds - a way to build Europe - PI08-1359, PI14-0613 the European Commission grants FOOD-CT-2006-036224-HIWATE the Catalan Government DURSI grant 2014SGR647. MCT was funded by a Canadian Institutes of Health Research Fellowship.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026