RT Journal Article
T1 Single and joint effects of cadmium and selenium on bioaccumulation, oxidative stress and metabolomic responses in the clam Scrobicularia plana
A1 Trombini, Chiara
A1 Rodríguez Moro, Gema
A1 Ramírez Acosta, Sara
A1 Gómez Ariza, José Luis
A1 Blasco Moreno, Julián
A1 García Barrera, Tamara
AB Selenium (Se) is a vital trace element for many living organisms inclusive of aquatic species. Although the antagonistic action of this element against other pollutants has been previously described for mammals and birds, limited information on the join effects in bivalves is available. To this end, bivalves of the species Scrobicularia plana were exposed to Se and Cd individually and jointly. Digestive glands were analysed to determine dose-dependent effects, the potential influence of Se on Cd bioaccumulationas well as the possible recover of the oxidative stress and metabolic alterations induced by Cd. Selenium co-exposure decreased the accumulation of Cd at low concentrations. Cd exposure significantly altered the metabolome of clams such as aminoacyltRNA biosynthesis, glycerophospholipid and amino acid metabolism, while Se co-exposure ameliorated several altered metabolites such asLysoPC (14:0), LysoPE (20:4), LysoPE (22:6), PE (14:0/18:0), PE (20:3/18:4) andpropionyl-Lcarnitine. Additionally, Se seems to be able to regulate the redox status of the digestive gland of clams preventing the induction of oxidativedamage in this organ. This study shows the potential Se antagonism against Cd toxicity in S. plana and the importance to study join effects of pollutants to understand the mechanism underlined the effects.
PB Elsevier
SN 0045-6535
YR 2022
FD 2022
LK https://hdl.handle.net/10272/21411
UL https://hdl.handle.net/10272/21411
LA eng
NO Trombini, C., Rodríguez-Moro, G., Ramírez Acosta, S., Gómez Ariza, J. L., Blasco, J., & García-Barrera, T. (2022). Single and joint effects of cadmium and selenium on bioaccumulation, oxidative stress and metabolomic responses in the clam Scrobicularia plana. In Chemosphere (Vol. 308, p. 136474). Elsevier BV. https://doi.org/10.1016/j.chemosphere.2022.136474
NO This study has been carried out within the research projects (CTM2012-38720-C03-03 and CTM2016-75908-R) founded by the Spanish Ministry of Economy and Competitiveness, who also provided a pre-doc grant for Chiara Trombini (BES-2013-063426), and the project PGC-2018- 096608-B-C21 from the Spanish Ministry of Science and innovation (MCIN). (Generaci´on del Conocimiento. MCIN/AEI/ 10.13039/501100011033/FEDER “Una manera de hacer Europa”). Authors are grateful to FEDER (European Community) for financial support, Grant UNHU13-1E-1611. Rodríguez-Moro, G. thanks to Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020) and European Union for a post-doctoral grant (DOC_01115). Funding for open access charge: Universidad de Huelva / CBUA.
DS Repositorio Institucional de la Universidad de Huelva
RD 13 jul 2026