RT Journal Article
T1 Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics
A1 Rodríguez Padilla, Ángela
A1 Morales Martín, Germán
A1 Pérez Quintero, Rocío
A1 Gómez Salgado, Juan
A1 Ruiz Frutos, Carlos
AB Diversion colitis is a non-specific inflammation of a defunctionalised segment of the colonafter a temporary stoma has been performed. This inflammation is associated with an alteration ofcertain inflammatory serum markers. The aims of this study were, firstly, to evaluate the modificationof inflammatory biomarkers after stimulation with probiotics prior to closure of the protectiveileostomy. Secondly, to identify if a relationship could be established between the severity of diversioncolitis and the alteration of inflammatory biomarkers in the blood. A prospective, randomized,double-blind, controlled study was conducted. Patients who underwent surgery for colorectal carcinomawith protective ileostomy between January 2017 and December 2018 were included, pendingreconstructive surgery and with diversion colitis as diagnosis. The sample was randomly dividedinto a group stimulated with probiotics (SG) (n = 34) and a control group (CG) (n = 35). Histologicaland endoscopic changes were evaluated after stimulation, after restorative surgery and during theshort-term follow-up after surgery, including the correlation with pro-inflammatory biomarkers inblood. As main findings, a significant decrease in C-reactive protein (CRP), Neutrophil/lymphocyteratio (NLR ratio), and monocyte/lymphocyte ratio (LMR ratio) was observed in the SG versus theCG with a p < 0.001. A significant increase in transferrin values and in the platelet/lymphocyteratio (PLR) was observed in the SG versus CG after stimulation with probiotics with a p < 0.001.A normalisation of CRP and transferrin levels was observed in the third month of follow-up afterclosure ileostomy, and NLR, LMR and PLR ratios were equal in both groups. Decreased modifiedGlasgow prognostic score was found in SG compared to CG after probiotic stimulation (p < 0.001).The endoscopic and histological severity of diversion colitis is associated with a greater alterationof blood inflammatory biomarkers. The stimulation with probiotics prior to reconstructive surgerypromotes an early normalization of these parameters.
PB MDPI
SN 2218-273X
YR 2021
FD 2021-05
LK http://hdl.handle.net/10272/19942
UL http://hdl.handle.net/10272/19942
LA eng
NO Rodríguez Padilla, Á., Morales Martín, G., Pérez Quintero, R., Gómez Salgado, J., & Ruiz Frutos, C. (2021). Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics. Biomolecules, 11(5), 684. DOI: https://doi.org/10.3390/biom11050684
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026