RT Journal Article
T1 Recommendations and Best Practices for Standardizing the Pre-Analytical Processing of Blood and Urine Samples in Metabolomics
A1 González Domínguez, Raúl
A1 González Domínguez, Álvaro
A1 Fernández Recamales, María Ángeles
AB Metabolomics can be significantly influenced by a range of pre-analytical factors, suchas sample collection, pre-processing, aliquoting, transport, storage and thawing. This thereforeshows the crucial need for standardizing the pre-analytical phase with the aim of minimizing theinter-sample variability driven by these technical issues, as well as for maintaining the metabolicintegrity of biological samples to ensure that metabolomic profiles are a direct expression of thein vivo biochemical status. This review article provides an updated literature revision of the mostimportant factors related to sample handling and pre-processing that may affect metabolomics results,particularly focusing on the most commonly investigated biofluids in metabolomics, namely bloodplasma/serum and urine. Finally, we also provide some general recommendations and best practicesaimed to standardize and accurately report all these pre-analytical aspects in metabolomics research.
PB MDPI
SN 2218-1989
YR 2020
FD 2020-06
LK http://hdl.handle.net/10272/18307
UL http://hdl.handle.net/10272/18307
LA eng
NO González Domínguez, R., González Domínguez, Á., Sayago, A., & Fernández Recamales, Á. (2020). Recommendations and Best Practices for Standardizing the Pre-Analytical Processing of Blood and Urine Samples in Metabolomics. Metabolites, 10(6), 229. DOI: https://doi.org/10.3390/metabo10060229
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026