Pizarro Javier, Juan DiegoSchmidtke, Inga L.Nova, AinaraRomero Fructos-Vázquez, ManuelPérez Romero, Pedro José2022-12-122022-12-122022-05-25Pizarro, J. D., Schmidtke, I. L., Nova, A., Fructos, M. R., & Pérez, P. J. (2022). Selective Functionalization of Arene C(sp2)–H Bonds by Gold Catalysis: The Role of Carbene Substituents. In ACS Catalysis (Vol. 12, Issue 12, pp. 6851–6856). American Chemical Society (ACS). https://doi.org/10.1021/acscatal.2c017132155-5435 (electrónico)https://hdl.handle.net/10272/21352The complete regioselective incorporation of carbene units to nonactivated arene rings has been achieved employing gold(I) catalysts bearing alkoxydiaminophosphine ligands, with readily available, nonelaborated ethyl 2-phenyl-diazoacetate as the carbene source. These results are in contrast with the scarce precedents which required highly elaborated diazo substrates. Density functional theory (DFT) calculations have revealed the important role of the R group in the C(R)CO 2Et fragment, which dramatically affects the energy profile of this transformation.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Aromatic compoundsCarbene compoundsCatalystsFunctionalizationHydrocarbonsjournal article10.1021/acscatal.2c01713open access