Olmos Verge, AndreaGava, RiccardoCaballero Bevia, AnaPérez Romero, Pedro José2019-02-132019-02-132018Olmos, A., Gava, R., Noverges, B., Bellezza, D., Jacob, K., Besora, M., Caballero Bevia, A., Pérez Romero, P. J. (2018). Measuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophiles. Angewandte Chemie International Edition, 57(42), 13848-13852. https://doi.org/10.1002/anie.2018074481433-78511521-3773 electrónicohttp://hdl.handle.net/10272/15974We report quantitative measurements of the relative reactivities of a series of C-H bonds of gaseous or liquid CnH2n+2 alkanes (n = 1-8, 29 different C-H bonds) towards insitu generated electrophiles (copper, silver, and rhodium carbenes), with methane as the reference. This strategy surpasses the drawback of previous model reactions of alkanes with strong electrophiles suffering from C-C cleavage processes, which precluded direct comparison of the relative reactivities of alkane C-H bonds.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/AlkanesC-H bond functionalizationElectrophilicityMetal carbene complexesNucleophilicityMeasuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophilesjournal article10.1002/anie.201807448open access