Becerra Herrera, MercedesSayago Gómez, AnaBeltrán Lucena, Rafael2019-03-122019-03-122017-09Mercedes Becerra Herrera, Ana Sayago Gómez, Rafael Beltrán Lucena. Exploring antioxidant reactivity and molecular structure of phenols by means of two coupled assays using fluorescence probe (2,3-diazabicyclo[2.2.2]oct-2-ene, DBO) and free radical (2,2-diphenyl-1-picrylhydrazyl, DPPH·). Journal of Chemical Sciences Vol. 129, No. 9, September 2017, pp. 1381–1390. ISSN: 0974-3626. DOI 10.1007/s12039-017-1331-10974-3626http://hdl.handle.net/10272/16066Phenolic compounds can be considered as the most important bioactive compounds in Mediterranean diet. However, many of the complex connections between phenols antioxidant reactivity and their molecular structure remain unsolved. To shine light on these issues, the antioxidant reactivity of 15 relevant phenolic compounds was studied. Two different analytical approaches were combined: (a) the well-established 2,2- diphenyl-1-picrylhydrazyl (DPPH·) stable free radical assay, and (b) the 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) fluorescent probe assay. The results obtained confirm how certain structural features (i.e., hydroxyl and methoxy groups, alkyl and alkenyl chains) play a critical role in the singular antioxidant response exhibited by each phenolic compound. This knowledge provides decisive information to select a specific phenolic compound as an antioxidant additive or for the chemical design of new antioxidants.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Phenolic compoundsDPPH2,3-diazabicycloDBOAntioxidant activityStructure relationshipjournal article10.1007/s12039-017-1331-1open access