Vila García, AlejandroBlandón Cumbreras, Francisco G.Pauls, MikeDíaz Abellás, MauroBlanco Gómez, ArturoPeinador Veira, CarlosRemón Ruiz, PatriciaBannwarth, ChristophPischel, UweGarcía Romero, Marcos Daniel2026-06-092026-06-092026Vila, A., Blandón-Cumbreras, F. G., Pauls, M., Díaz-Abellás, M., Blanco-Gómez, A., Peinador, C., Remón, P., Bannwarth, C., Pischel, U., & García, M. D. (2026). Photovermellogens: Minimalistic Pyridinium-Based Acylhydrazones with Photoswitchable Basicity for Operation in Aqueous Media. The Journal of Organic Chemistry. https://doi.org/10.1021/acs.joc.5c029620022-32631520-6904 (electrónico)https://hdl.handle.net/10272/28497Examples of a new class of synthetically straightforward and hydrolytically inert photoswitchable acylhydrazones, named photovermellogens, have been successfully developed and comprehensively studied using state-of-the-art spectroscopic and computational techniques. These compounds present photoswitchable basicity, with irradiation promoting E→Z photoisomerizations, which result in the generation of a less acidic species. The observed ΔpKa values > 1.5 within the biologically relevant window underscore the potential of photovermellogens as versatile platforms for light-triggered pH control.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article10.1021/acs.joc.5c02962open access2306 Química Orgánica2307 Química Física