López Carbón, VerónicaSayago Gómez, AnaGonzález Domínguez, RaúlFernández Recamales, María Ángeles2019-10-302019-10-302019-09López Carbón, V., Sayago Gómez, A., González Domínguez, R., Fernández Recamales, Á. (2019). Simple and Efficient Green Extraction of Steviol Glycosides from Stevia rebaudiana Leaves. Foods, 8(9), 402. DOI: https://doi.org/10.3390/foods80904022304-8158http://hdl.handle.net/10272/16959The food industry has currently shown great interest in alternative sweeteners to sugars with the aim of producing healthier products. In light of this, steviol glycosides are natural low-caloric sweeteners present in Stevia rebaudiana, which have additionally been described as bioactive components with potential therapeutic properties. In this work, a green method for the extraction of steviol glycosides from stevia leaves was optimized by applying a factorial screening design of five variables (time, temperature, agitation, grinding, and sample–solvent ratio) and the subsequent response surface design of Box-Behnken. The optimized extraction method allows for the recovery of stevia sweeteners in a simple and e cient manner by using tap water as the extractant, without the application of an auxiliary energy source to reduce costs, thus representing an interesting strategy for their industrial-scale production.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Steviol glycosidesGreen extractionStevia leavesSteviosideRebaudioside Ajournal article10.3390/foods8090402open access