Moreno Rodríguez, AnabelRamírez Rodríguez, ManuelDíaz Requejo, María MarPérez Romero, Pedro José2021-04-192021-04-192020-03Rodríguez, AM., Rodríguez, M.R., Díaz Requejo, M.M., Pérez Romero, P.J.: "Pyrrole Functionalization by Copper‐Catalyzed Nitrene Transfer Reactions". Israel Journal of Chemistry. Volume 60, Issue 3-4 (2020). https://doi.org/10.1002/ijch.2019001810021-21481869-5868 (electrónico)http://hdl.handle.net/10272/19698The catalytic functionalization of pyrroles by incorporation of a nitrene group is reported. The Cα‐H bond of 1H‐pyrrole is amidated upon the formal insertion of the NTs (Ts=p‐toluenesulfonyl) group catalyzed by TpBr3Cu(NCMe) (TpBr3=hydrotris(3,4,5‐tribromo‐pyrazolyl)borate). N‐substituted pyrroles also verify the same transformation. The mechanism proposal is similar to that previously described for benzene amidation with the same catalyst and PhI=NTs, which takes place through aziridine formation, ring opening and 1,2‐hydrogen shift. A cascade reaction involving the coupling of 2,5‐dimethylfuran, 1,2,3‐trimethyl‐pyrrole and a nitrene NTs group is also described, leading to a 1,2‐dihydropyridine‐imine compound.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Nitrene transferPyrrole functionalizationC-H amidationCopper catalysisCopper nitrenejournal article10.1002/ijch.201900181open access23 Química