Ávarez, MaríaGava, RiccardoRamírez Rodríguez, ManuelRull, Silvia G.Pérez Romero, Pedro José2019-04-252019-04-252017Álvarez, M., Gava, R., Rodríguez, M. R., Rull, S. G., & Pérez, P. J. (2017). Water as the Reaction Medium for Intermolecular C–H Alkane Functionalization in Micellar Catalysis. ACS Catalysis, 7(5), 3707-3711. https://doi.org/10.1021/acscatal.6b036692155-5435http://hdl.handle.net/10272/16193A series of alkanes CnH2n+2 have been functionalized in water as the reaction medium, using a silver-based catalyst, upon insertion of carbene (CHCO2Et from N2CHCO2Et) groups into their carbon-hydrogen bonds of hexane, cyclohexane or 2-methylbutane, among others. The regioselectivity toward the distinct reaction sites is identical to that found in neat alkane, the water-based system allowing the use of a much shorter excess of the hydrocarbon. This is the first example of the intermolecular functionalization of alkanes with this strategy in water. The functionalized alkanes partially undergoes a incorporation of a second carbene unit to provide a-(acyloxy)acetates, in an unprecedented tandem reaction of this nature.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Alkane functionalizationC-H activationCatalysis in waterCarbene transferCopper and silver catalystsjournal article10.1021/acscatal.6b03669open access