Carreras, JavierCaballero Bevia, AnaPérez Romero, Pedro José2019-02-132019-02-132018Carreras, J., Caballero, A., & Pérez, P. J. (2018). Enantio- and Diastereoselective Cyclopropanation of 1-Alkenylboronates: Synthesis of 1-Boryl-2,3-Disubstituted Cyclopropanes. Angewandte Chemie International Edition, 57(9), 2334-2338. https://doi.org/10.1002/anie.2017104151433-78511521-3773 electrónicohttp://hdl.handle.net/10272/15969A novel, highly enantio- and diastereoselective synthesis of 1-boryl-2,3-disubstituted cyclopropanes has been developed by means of the cyclopropanation of alkenylboronates with ethyl diazoacetate in the presence of catalytic amounts of a chiral copper(I) complex. The products can also be directly accessed from alkynes through an operationally simple, sequential hydroboration–cyclopropanation protocol. The resulting enantioenriched 1-boryl-2,3-disubstituted cyclopropanes are versatile synthetic intermediates that undergo further transformations at the carbon–boron bond.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/AlkenylboronatesAsymmetric catalysisCyclopropanesCopperHydroborationjournal article10.1002/anie.201710415open access