Herrera Quintana, LourdesGamarra Morales, YeniferVázquez Lorente, HéctorMolina López, JorgeCastaño Pérez, JoséMachado Casas, Juan FranciscoCoca Zúñiga, RamónPérez Villares, José MiguelPlanells, Elena2021-09-022021-09-022021Herrera-Quintana, L., Gamarra-Morales, Y., Vázquez-Lorente, H., Molina-López, J., Castaño-Pérez, J., Machado-Casas, J. F., Coca-Zúñiga, R., Pérez-Villares, J. M., & Planells, E. (2021). Bad Prognosis in Critical Ill Patients with COVID-19 during Short-Term ICU Stay regarding Vitamin D Levels. Nutrients, 13(6), 1988. https://doi.org/10.3390/nu130619882072-6643 (electrónico)http://hdl.handle.net/10272/20052Background and aims: Vitamin D inadequacy may be involved in the mechanisms of SARS-CoV-2 infection and in potential risk factors for disease propagation or control of coronavirus disease 2019 (COVID-19). This study assessed a short-term evolution of vitamin D status and its influence upon different clinical parameters in critically ill patients with COVID-19. Methods: A prospective analytical study in which 37 critically ill volunteers between 41 and 71 years of age with COVID-19 were evaluated at baseline and three days of intensive care unit (ICU) stay. 25-OH-D3 and 25-OH-D2 were analyzed by liquid chromatography–tandem mass spectrometry and total 25-OH-D levels were calculated as the sum of both. Results: All patients presented low 25-OH-D levels at baseline, decreasing total 25-OH-D (p = 0.011) mainly through 25-OH-D2 (p = 0.006) levels during ICU stay. 25-OH-D2 levels decreased a mean of 41.6% ± 89.6% versus 7.0% ± 23.4% for the 25-OH-D3 form during the ICU stay. Patients who did not need invasive mechanical ventilation presented higher levels of 25-OH-D2 at baseline and follow-up. Lower 25-OH-D and 25-OH-D3 levels were associated with higher D-dimer at baseline (p = 0.003; p = 0.001) and at follow up (p = 0.029), higher procalcitonin levels (p = 0.002; p = 0.018) at follow up, and lower percentage lymphocyte counts (p = 0.044; p = 0.040) during ICU stay. Conclusions: Deficient vitamin D status in critical patients was established at the admission and further worsened after three days of stay. Lower vitamin D levels were related to key altered clinical and biochemical parameters on patients with SARS-CoV-2 infection. Given the different response of the 25-OH-D3 and 25-OH-D2 forms, it would be useful to monitor them on the evolution of the critically ill patientengAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Coronavirus disease 2019SARS-CoV-2Vitamin DCritical careIntensive care patientjournal article10.3390/nu13061988open access5899 Otras Especialidades Pedagógicas