Pizarro Javier, Juan DiegoMorán González, LucíaGonzález Fernández, IvánMaseras, FeliuRomero Fructos-Vázquez, ManuelPérez Romero, Pedro José2023-09-222023-09-222023-07Pizarro, J-D., Morán‐González, L., González‐Fernández, I., Maseras, F., Romero-Fructos, M., & Pérez, P. J. (2023). Selective C−H Bond Functionalization of Unprotected Indoles by Donor‐Acceptor Carbene Insertion. In Advanced Synthesis & Catalysis. Wiley. https://doi.org/10.1002/adsc.2023002521615-41501615-4169 (electrónico)https://hdl.handle.net/10272/22449Copper catalysts containing alkoxydiaminophosphine (ADAP) ligand catalyze the selective C3- H functionalization of unprotected indoles upon carbene transfer from donor-acceptor diazo compounds, the N-H bond remaining unaltered during the transformation. Mechanistic studies, including DFT calculations, allows proposing the existence of two competitive pathways, none of them occurring through the formation of cyclopropane intermediates, at variance with previously reported systems.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Indole functionalizationCarbene transferSelective C-H functionalizationN-H bondDonor-acceptorjournal article10.1002/adsc.202300252open access23 Química