Díaz Requejo, María MarPérez Romero, Pedro José2026-01-072026-01-072025-08-21M. Mar Díaz-Requejo, Pedro J. Pérez, Weak interactions are crucial for better enantioselections, Chem Catalysis, Volume 5, Issue 8, 2025, 101496, ISSN 2667-1093, https://doi.org/10.1016/j.checat.2025.101496.https://hdl.handle.net/10272/27602In this issue of Chem Catalysis, Schomaker, Liu, and co-workers describe an enantioselective intramolecular silver-catalyzed nitrene transfer (NT) that forms chiral six-membered rings via C–H amidation. They use density functional theory (DFT) calculations to model initial experimental data, which provide crucial insights into the relevance of non-covalent interactions in enantioselection. These findings guide the design of novel ligands that enhance enantiomeric excess in the asymmetric amidation of diverse C–H bonds.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Catalystsjournal article10.1016/j.checat.2025.101496open access23 Química