Sánchez Cid, PabloRomero, AlbertoDíaz Blanco, Manuel JesúsPaz Báñez, María Violante dePérez Puyana, Víctor2023-05-292023-05-292023-03Sánchez-Cid, P., Romero, A., Díaz, M. J., de-Paz, M. V., & Perez-Puyana, V. (2023). Chitosan-based hydrogels obtained via photoinitiated click polymer IPN reaction. In Journal of Molecular Liquids (Vol. 379, p. 121735). Elsevier BV. https://doi.org/10.1016/j.molliq.2023.1217350167-73221873-3166 (electrónico)https://hdl.handle.net/10272/22139Chitosan (CTS) is a polysaccharide with a wide variety of applications in the biomedical field, owing to its outstanding disinfectant properties, biocompatibility and biodegradability, but with limited mechanical properties. The proposed strategy to improve CTS-based hydrogel properties in this study is the formation of a semi-interpenetrating polymer network (semi-IPN). In this way, a photo-initiated radical click reaction was proposed to obtain a synthetic polymer, whose components were included in a CTS solution, resulting in the semi-IPN network after UV illumination. Different crosslinking degrees (CD) and CTS/polymer ratios were evaluated through rheological characterization, along with an assessment of both variables based on an experimental model design, obtaining that, for every CTS/polymer ratio, intermediate values of CD (8 %) offered the best rheological properties. In addition, chemical and microstructural characterization were carried out for selected hydrogels, obtaining consistent results according to rheological characterization, as the 1/1 CTS/polymer ratio with CD 8 % hydrogel displayed the most homogeneous pore size and distribution, consequently leading to the best rheological performance.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ChitosanInterpenetrated polymer network (IPN)Click chemistryPhoto-polymerizationRheologyjournal article10.1016/j.molliq.2023.121735open access2306 Química Orgánica