González Domínguez, ÁlvaroDomínguez Riscart, JesúsMillán Martínez, MaríaLechuga Sancho, Alfonso MaríaGonzález Domínguez, Raúl2023-07-062023-07-062023-01González-Domínguez, Á., Domínguez-Riscart, J., Millán-Martínez, M., Lechuga-Sancho, A. M., & González-Domínguez, R. (2023). Exploring the association between circulating trace elements, metabolic risk factors, and the adherence to a Mediterranean diet among children and adolescents with obesity. In Frontiers in Public Health (Vol. 10). Frontiers Media SA. https://doi.org/10.3389/fpubh.2022.10168192296-2565 (electrónico)https://hdl.handle.net/10272/22273Diet is one of the most important modifiable lifestyle factors for preventing and treating obesity. In this respect, the Mediterranean diet (MD) has proven to be a rich source of a myriad of micronutrients with positive repercussions on human health. Herein, we studied an observational cohort of children and adolescents with obesity (N = 26) to explore the association between circulating blood trace elements and the degree of MD adherence, as assessed through the KIDMED questionnaire. Participants with higher MD adherence showed better glycemic/insulinemic control and a healthier lipid profile, as well as raised plasma levels of selenium, zinc, cobalt, molybdenum, and arsenic, and increased erythroid content of selenium. Interestingly, we found that these MD-related mineral alterations were closely correlated with the characteristic metabolic complications behind childhood obesity, namely hyperglycemia, hyperinsulinemia, and dyslipidemia (p < 0.05, |r| > 0.35). These findings highlight the pivotal role that dietary trace elements may play in the pathogenesis of obesity and related disorders.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Childhood obesityTrace elementsMediterranean dietKIDMEDMulti-elemental analysisjournal article10.3389/fpubh.2022.1016819open access32 Ciencias Médicas