Fuentes Domínguez, María ÁngelesGava, RiccardoSaper, Noam I.Romero, Erik A.Caballero Bevia, AnaHartwig, John F.Pérez Romero, Pedro José2021-10-062021-10-062021-05Fuentes, M. Á., Gava, R., Saper, N. I., Romero, E. A., Caballero, A., Hartwig, J. F., & Pérez, P. J. (2021). Copper‐Catalyzed Dehydrogenative Amidation of Light Alkanes. Angewandte Chemie International Edition, 60(34), 18467–18471. https://doi.org/10.1002/anie.2021047370044-82491521-3757 (electrónico)http://hdl.handle.net/10272/20143The functionalization of C-H bonds in light alkanes, particularly to form C-N bonds, remains a challenge. We report the dehydrogenative coupling of amides with C1–C4 hydrocarbons to form N-alkyl amide products with tBuOOtBu as oxidant, and a copper complex of a phenanthroline-type ligand as catalyst. The reactions occurred in good yields in benzene or supercritical carbon dioxide as solvents. This strategy allowed for the determination of the relative reactivity of these alkane C-H bonds toward this amination process and showed, in contrast to prior work with larger alkanes, that the reactivity correlated with bond dissociation energies.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/journal article10.1002/anie.202104737open access23 Química