Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure

López Baltanás, RodrigoCanalejo Raya, AntonioMuñoz Castañeda, Juan R.2023-06-222023-06-222023-01López-Baltanás, R., Rodríguez-Ortiz, M. E., Díaz-Tocados, J. M., Martinez-Moreno, J. M., Membrives, C., Rodelo-Haad, C., Pendón Ruiz de Mier, M. V., Rodríguez, M., Canalejo, A., Almadén, Y., & Muñoz-Castañeda, J. R. (2023). Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure. In Antioxidants (Vol. 12, Issue 2, p. 283). MDPI AG. https://doi.org/10.3390/antiox120202832076-3921 (electrónico)https://hdl.handle.net/10272/22232Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly associated with cardiovascular disease (CVD) and in these patients Mg concentration is usually decreased. This study evaluated whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 nephrectomy, Nx) was used. Nephrectomized animals were fed a normal 0.1%Mg (MetS+Nx+Mg 0.1%) or a supplemented 0.6%Mg (MetS+Nx+Mg0.6%) diet; Sham-operated rats with MetS receiving 0.1%Mg were used as controls. Results: As compared to controls, the MetS+Nx-Mg0.1% group showed a significant increase in oxidative stress and inflammation biomarkers (lipid peroxidation and aortic interleukin-1b and -6 expression) and Endothelin-1 levels, a decrease in nitric oxide and a worsening in uremia and MetS associated pathology as hypertension, and abnormal glucose and lipid profile. Moreover, proteomic evaluation revealed changes mainly related to lipid metabolism and CVD markers. By contrast, in the MetS+Nx+Mg0.6% group, these parameters remained largely similar to controls. Conclusion: In concurrent MetS and CKD, dietary Mg supplementation reduced inflammation and oxidative stress and improved vascular function.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/MagnesiumMetabolic syndromeChronic kidney diseaseInflammationOxidative stressVascular dysfunctionDietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failurejournal article10.3390/antiox12020283open access32 Ciencias Médicas