Photovermellogens: Minimalistic Pyridinium-Based Acylhydrazones with Photoswitchable Basicity for Operation in Aqueous Media

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dc.contributor.authorVila García, Alejandro
dc.contributor.authorBlandón Cumbreras, Francisco G.
dc.contributor.authorPauls, Mike
dc.contributor.authorDíaz Abellás, Mauro
dc.contributor.authorBlanco Gómez, Arturo
dc.contributor.authorPeinador Veira, Carlos
dc.contributor.authorRemón Ruiz, Patricia
dc.contributor.authorBannwarth, Christoph
dc.contributor.authorPischel, Uwe
dc.contributor.authorGarcía Romero, Marcos Daniel
dc.date.accessioned2026-06-09T11:52:01Z
dc.date.available2026-06-09T11:52:01Z
dc.date.issued2026
dc.description.abstractExamples of a new class of synthetically straightforward and hydrolytically inert photoswitchable acylhydrazones, named photovermellogens, have been successfully developed and comprehensively studied using state-of-the-art spectroscopic and computational techniques. These compounds present photoswitchable basicity, with irradiation promoting E→Z photoisomerizations, which result in the generation of a less acidic species. The observed ΔpKa values > 1.5 within the biologically relevant window underscore the potential of photovermellogens as versatile platforms for light-triggered pH control.
dc.description.centerCIQSO
dc.description.departmentQuímica "Profesor José Carlos Vílchez Martín"
dc.description.sponsorshipThe authors are grateful for the funding received from the MCIN/AEI/10.13039/501100011033 and ERDF A way of making Europe (PID2022-137361NB-I00 for C.P./M.D.G., PID2020-119992GB-I00 and PID2023-152556NB-I00 for U.P. and predoctoral contract PRE2023-001520 for F.G.B.- C.), and the Consellería de Cultura, Educación e Universidade da Xunta de Galicia (ED431C 2022/39). M.D.-A. thanks Ministerio de Universidades for his predoctoral fellowship (FPU21/06302). A.B.-G. thanks the Consellería de Cultura, Educación e Universidade da Xunta de Galicia for his postdoctoral fellowship (ED481D-2024-020). M.D.G. thanks CESGA (Xunta de Galicia) for computational time. C.B. acknowledges funding from the Federal Ministry of Education and Research (BMBF) and the Ministry of Culture and Science of the German State of North Rhine-Westphalia (MKW) under the Excellence Strategy of the Federal Government and the Länder (RWTH JPI Fellowship), as well as funding from the MKW via the NRW Rückkehrprogramm.
dc.identifier.citationVila, A., Blandón-Cumbreras, F. G., Pauls, M., Díaz-Abellás, M., Blanco-Gómez, A., Peinador, C., Remón, P., Bannwarth, C., Pischel, U., & García, M. D. (2026). Photovermellogens: Minimalistic Pyridinium-Based Acylhydrazones with Photoswitchable Basicity for Operation in Aqueous Media. The Journal of Organic Chemistry. https://doi.org/10.1021/acs.joc.5c02962
dc.identifier.doi10.1021/acs.joc.5c02962
dc.identifier.issn0022-3263
dc.identifier.issn1520-6904 (electrónico)
dc.identifier.urihttps://hdl.handle.net/10272/28497
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.unesco2306 Química Orgánica
dc.subject.unesco2307 Química Física
dc.titlePhotovermellogens: Minimalistic Pyridinium-Based Acylhydrazones with Photoswitchable Basicity for Operation in Aqueous Media
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication48a77d6a-af6c-4e1b-9e9a-65dbe12a6363
relation.isAuthorOfPublication167a3481-ecaf-42e1-b0e1-8fee1d243110
relation.isAuthorOfPublication.latestForDiscovery48a77d6a-af6c-4e1b-9e9a-65dbe12a6363

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