Selective C−H Bond Functionalization of Unprotected Indoles by Donor-Acceptor Carbene Insertion

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dc.contributor.authorPizarro Javier, Juan Diego
dc.contributor.authorMorán González, Lucía
dc.contributor.authorGonzález Fernández, Iván
dc.contributor.authorMaseras, Feliu
dc.contributor.authorRomero Fructos-Vázquez, Manuel
dc.contributor.authorPérez Romero, Pedro José
dc.date.accessioned2023-09-22T11:04:44Z
dc.date.available2023-09-22T11:04:44Z
dc.date.issued2023-07
dc.description.abstractCopper catalysts containing alkoxydiaminophosphine (ADAP) ligand catalyze the selective C3- H functionalization of unprotected indoles upon carbene transfer from donor-acceptor diazo compounds, the N-H bond remaining unaltered during the transformation. Mechanistic studies, including DFT calculations, allows proposing the existence of two competitive pathways, none of them occurring through the formation of cyclopropane intermediates, at variance with previously reported systems.es_ES
dc.description.centerCIQSO
dc.description.departmentQuímica "Profesor José Carlos Vílchez Martín"
dc.description.sponsorshipWe thank to Ministerio de Ciencia e Innovación for Grants PID2020-113797RB-C21, PID2020-112825RB-I00 and CEX2019-000925-S. We also thank Junta de Andalucía (P18-1536) and Universidad de Huelva (P. O.Feder UHU-202024). I.-G. F thanks the Investigo Program for a contract. L. M.-G. thanks Generalitat de Catalunya for an FI-Agaur predoctoral contract, 2022FI−B2000621.es_ES
dc.identifier.citationPizarro, J-D., Morán‐González, L., González‐Fernández, I., Maseras, F., Romero-Fructos, M., & Pérez, P. J. (2023). Selective C−H Bond Functionalization of Unprotected Indoles by Donor‐Acceptor Carbene Insertion. In Advanced Synthesis & Catalysis. Wiley. https://doi.org/10.1002/adsc.202300252es_ES
dc.identifier.doi10.1002/adsc.202300252
dc.identifier.issn1615-4150
dc.identifier.issn1615-4169 (electrónico)
dc.identifier.urihttps://hdl.handle.net/10272/22449
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.otherIndole functionalizationes_ES
dc.subject.otherCarbene transferes_ES
dc.subject.otherSelective C-H functionalizationes_ES
dc.subject.otherN-H bondes_ES
dc.subject.otherDonor-acceptores_ES
dc.subject.unesco23 Químicaes_ES
dc.titleSelective C−H Bond Functionalization of Unprotected Indoles by Donor-Acceptor Carbene Insertiones_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication4c3de728-2a65-41a6-ad65-81e751665290
relation.isAuthorOfPublicationc6f8222a-d8d2-4736-baa6-4a2330bdf6b6
relation.isAuthorOfPublication.latestForDiscovery4c3de728-2a65-41a6-ad65-81e751665290

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