Exclusive Aromatic vs Aliphatic C-H Bond Functionalization by Carbene Insertion with Gold-based Catalysts

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Publication date

2011

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Ingeniería Química, Química Física y Ciencias de los Materiales

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Center

CIQSO

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http://hdl.handle.net/10272/11556

DOI

10.1021/om200206m

Abstract

The direct functionalization of aromatic C-H bonds by carbene insertion from diazocompounds catalyzed by gold complexes with N-heterocyclic ligands is described. The reaction is completely selective toward the Csp2-H bonds, other Csp3-H bonds remaining unreacted. A study with a several NHC ligands in Au(I) and Au(III) complexes has been performed. A potential application in profen derivatives has also been developed

Keywords

Gold catalysis; Carbene transfer; C-H functionalization; NHC ligands; Diazo compounds

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Bibliographic citation

Rivilla de la Cruz, I., Gómez Emeterio, B.P., Romero Fructos-Vazquez, M., Díaz Requejo, M.M., Pérez Romero, P.J.: "Exclusive Aromatic vs Aliphatic C–H Bond Functionalization by Carbene Insertion with Gold-Based Catalysts". Organometallics. Vol. 30 (10), págs. 2855–2860, (2011). DOI: 10.1021/om200206m

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