Toward Light-Controlled Supramolecular Peptide Dimerization

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acs.joc.1c00464.pdf (1.54 MB)

Publication date

2021-06-01

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Química "Profesor José Carlos Vílchez Martín"

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Center

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https://hdl.handle.net/10272/21354

DOI

10.1021/acs.joc.1c00464

Abstract

The selective photodeprotection of the NVoc-modified FGG tripeptide yields the transformation of its 1:1 receptor−ligand complex with cucurbit[8]uril into a homoternary FGG2@CB8 assembly. The resulting lightinduced dimerization of the model peptide provides a tool for the implementation of stimuli-responsive supramolecular chemistry in biologically relevant contexts.

Keywords

Dimerization; Irradiation; Light; Peptides and Proteins; Receptors

Unesco Subjects

23 Química

Bibliographic citation

Fernandes, R. J., Remón, P., Moro, A. J., Seco, A., Ferreira, A. S. D., Pischel, U., & Basílio, N. (2021). Toward Light-Controlled Supramolecular Peptide Dimerization. The Journal of Organic Chemistry, 86(12), 8472–8478. https://doi.org/10.1021/acs.joc.1c00464

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